Amphetamine users may use other drugs such as minor tranquillisers, cannabis, alcohol or heroin to cope with some of the undesirable effects of amphetamines. These users may develop a rollercoaster dependence on several drugs. For example, some people may need amphetamines each day to get them going and minor tranquillisers each night to get them to sleep. This type of dependence can lead to a variety of very serious physical and psychological problems. Using more than one drug (poly-drug use) increases the harm associated with drug use.

If amphetamines are combined with alcohol, users may not feel the effects associated with alcohol straightaway. However, blood alcohol concentration still goes up and their motor skills (such as coordination and reflexes) are still impaired.

Combining amphetamines with other stimulants such as ecstasy or cocaine can greatly influence the immediate effects. The result can be unpredictable and the effects may be similar to taking a very large dose of amphetamines.

Amphetamines and Mental Health Problems:

Amphetamine use can cause anxiety, depression, paranoia and psychosis in those people who have vulnerability to mental health problems.